No Cura profile is right for your unique conditions. Given the various conditions of your workspace, heated bed, etc your 'perfect' print temperature will be different. If your profiles aren't working exactly, you'll need to test the conditions. But don't worry, with a little work your printer will work harmoniously in your workspace.
Your ambient and heated bed temperature can have an effect on your print. The ambient temperature of your workspace might cause for extruded material to run. Try to maintain your ambient temperature at about 72°F.
Over the course of years of printing, we've found that every workspace has unique variables. Don't get us wrong. We've finessed the profiles over years empirical testing. The printing profiles identified through Cura are only starting points however. To find the perfect temperature, we recommend that you increase the extrusion temperature by 10°F and print a test file. I've included several files for you to test with. If the problem persists, increase temperature and try again. With a little persistence you'll arrive at your perfect temperature.
If the problem persists however, please email email@example.com. Our technical support team is standing by to help.